A reliable blood volume expander

BioFLEX ISOPLASMA 4% I.V.F
A reliable blood volume expander

Question:
What is ISOPLASMA?

Answer:
ISOPLASMA is the only colloid blood expander registered in Nigeria and manufactured by Biomedical LTD. It is made from a pharmaceutical grade polymer called Polyvinylpyrrolidone or Povidone and other salts (NaCI and KCI). These polymers have K numbers which depict viscosity and therefore relative solubility. The K12 and K30 forms, which are free from endotoxins and suitable for use as injectibles are used in Biomedical’s formulation of ISOPLASMA. ISOPLASMA is an isotonic 4% w/v solution of polyvinylpyrrolidone.

It is an inert solution with colloid osmotic properties given to restore and maintain blood volume. While ISOPLASMA is not a substitute for red blood cells it helps to increase and maintain blood volume that suddenly drops due to acute hemorrhage from open cuts and burns sustained in accidents (domestic, road or natural accidents) and fire disasters.

Question:
What are the advantages of using ISOPLASMA?

Answer:
Advantages of ISOPLASMA for blood transfusion therapy;
• It can be readily used in emergencies
• It can be used in instances where the patient has a rare blood type
• There is no need for cross matching us the standard ABO blood group system
• ISOPLASMA does not necessarily require any special storage conditions. It can be stored as any other IV Fluids. Hence the need for anticoagulants is eliminated with ISOPLASMA
• It has a longer shelf life than blood.
• It can be used in cases of hypovolaemia where the patient cannot tolerate the high volumes of crystalloid expanders required to maintain blood flow.
• Is acceptable by people of all walks of life and religious beliefs.
• It is packaged in bags which are chemically inert, sterile, pyrogen free, transparent and well sealed ensuring the absence of microbes. The bags are also elastic and flexible; collapsing as the content is withdrawn thus eliminating the possibility of air embolism.
• ISOPLASMA is useful during post surgical operations; As much as 1000ml can be infused over 24 hrs. Further daily doses of 500ml can be given over the next few days depending on the patients needs.
• COST benefits: ISOPLASMA is comparatively far more cost effective because it is more affordable than blood even at 30% – 50% wholesale marked up shelve price! Hence with ISOPLASMA Transfusion Therapy can be done at greatly reduced cost to the patient and yet highly profitable in the business sense to a hospital.

Question:
What other important things can be said about ISOPLASMA?
Answer:

Blood alternatives can be categorized broadly as blood substitutes and blood volume expanders.
TYPES OF BLOOD ALTERNATIVES
Blood Substitutes Blood Volume expanders
These are products designed to perform, temporarily, as blood, specifically in terms of oxygen carrying capacity or supplementing red blood cell content These counter hypovolaemia (as seen in a severe burns patient, or trauma resulting in shock) where up to 40% of plasma has been lost by helping to circulate remaining RBCs
There are two main types of substitutes available, oxygen replacement therapies and red blood cell replacement There are two types of volume expanders, crystalloid and colloid
Oxygen replacement therapies are of two types, haemoglobin based products and perfluorocarbons (PFC’s) which can carry 02, CO2 and NO like RBCs Crystalloid expanders include physiologic saline, ringers lactate and dextrose 5% in water
RBC replacement therapies include pre operative erythropoietin administration that cause bone marrow to make new RBCs Colloid expanders’ include povidone, dextran, hydroxethyl, starch (HES), albumins and gelatins

About Crystalloids blood volume expanders:
• Crystalloid types are traditionally used in emergencies but are poorly sustained. This is because they are salt or sugar based solutions with low molecular weight and high osmotic properties. Therefore are readily absorbed and not available in the system for a long time and thus require large volumes in therapy.
About Colloids blood volume expanders:
• Colloid types are just as useful in emergencies and they are not as readily absorbed by the system. This is because they have a larger molecular weight and are more viscous. Therefore they sustain blood volume for longer periods than crystalloids. Colloid plasma expanders are viscous because they are made from long chains of polymers.
ISOPLASMA as a Colloid blood expander:
• It is made from a pharmaceutical grade polymer called polyvinylpyrrolidone or povidone and other salts (NaCI and KCI).
• These polymers have K numbers which depict viscosity and therefore relative solubility.
• The K12 and K30 forms, which are free from endotoxins and suitable for use as injectibles are used in Biomedical formulations.
Indications and Contra-indications of ISOPLASMA (4%):
• Pack Size: 500m1
• Components: Povidone, KCI, NaCI
• Concentration: Na+ (14.4mM), K+ (0.67mM), Cl- (15.07mM)
• Indicated for: Hypovoiaemia, Haemorrhage, Shock, Trauma
• Contra- Indicated for: Povidone hypersensitivity, Cardiac, renal, hepatic insufficiency and Hypernatremia
Summary:
• Blood transfusions are an important aspect of critical care.
• There are some limitations associated with conventional whole blood transfusions.
• Some of these limitations are addressed by blood alternatives.
• Blood expanders are the most readily available and safe type of alternative.
• BioFLEX ISOPLASMA is one of the leading brands in alternative blood transfusion therapy.

For Further Information, Please Contact:
+2348138853131
(Front desk)

+2349017445366
(Marketing Manager)

+2349017671475
(National Sales Coordinator)

Email: info@biomedicalng.com
Website: www.biomedicalng.com

References:
• National Blood Service: A SHORT HISTORY OF BLOOD TRANSFUSION COMPILED AND WRITTEN BY PHIL LEAROYD SCIENTIFIC & TECHNICAL TRAINING MANAGER — LEAD DDR LEEDS BLOOD CENTRE
• Blood therapy: from the clinic of hematology; www.poznanmeditine.org/content/…/Notes/IM-blood%20therapy.ppt
• Human blood group systems; www.wikipedia.com
• Blood Transfusion; www.wikipedia.com
• Allogeneic blood transfusion – the alternatives By N. Watson, MSc, MRPharmS and C. Taylor, MRCP, MRCPath
• Journal of Burn care & rehabilitation: January/February 1989

One Thought to “HIGHLIGHTING BioFLEX ISOPLASMA 4% I.V.F”

  1. Olajuwon Abayomi

    Really informative article and includes adequate basic information about BioFLEX ISOPLASMA 4% I.V.F

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